TWIST1 controls cellular metabolism and is involved in obesity- and angiogenesis-associated diseases (Pettersson et al., 2010; Wang et al., 2011; Nishioka et al., 2015; Mahmoud et al., 2016; Mammoto et al., 2016; Mahmoud et al., 2017). This evidence concerns the gene TWIST1 and obesity due to melanocortin 4 receptor deficiency.