Multiple groups have reported that stimulation of angiogenesis in adipose tissue of obese rodents by increasing angiogenic gene expression (e.g., VEGFA, VEGFB, FLT1, FOXO, Angiopoietin2) not only improves local adipose tissue function, but also counteracts systemic metabolic disorders (Sun et al., 2012; Sung et al., 2013; Robciuc et al., 2016; An et al., 2017; Rudnicki et al., 2018; Seki et al., 2018). The gene discussed is FLT1; the disease is Other metabolic disease.