The distribution pattern of TWIST1 and TWIST2 seems to be different; the levels of TWIST1 are higher in subcutaneous adipose tissues compared to visceral adipose tissues, which is strongly correlated with BMI and insulin resistance, while Twist2 is more ubiquitously expressed in the body (Pan et al., 2009; Pettersson et al., 2010). Here, TWIST2 is linked to Insulin resistance.