CCND1 and colorectal cancer: Overexpressed CDCA2 promotes proliferation of colorectal cancer (CRC) cells by targeting upregulation of cyclin D1 (CCND1) through activation of the phosphoinositide 3-kinase (PI3K)/AKT pathway, while a specific PI3K inhibitor (LY294002) blocks the pro-proliferative effect of CDCA2 on CRC cells (12).