Since the role of NF-κB in HCC is paradoxical (29), some studies have shown that NF-κB promotes inflammation-associated cancers (30), while inactivation of liver-specific NF-κB promotes the development and progression of HCC, suggesting that NF-κB may act as a tumor suppressor (31, 32). The gene discussed is NFKB1; the disease is hepatocellular carcinoma.