ascertained that indoleamine 2,3-dioxygenase1 (IDO1), which is known as an anti-inflammatory enzyme (48), can be produced by AML blasts in response to TIM-3/Gal-9-dependent interferon gamma (IFN-γ) production from natural killer (NK) cells (49). This evidence concerns the gene HAVCR2 and acute myeloid leukemia.