HAVCR2 and acute myeloid leukemia: reported that increased amounts of TIM-3 in plasma, probably due to its secretion from AML blasts, and the soluble form of TIM-3 (sTIM-3), which is formed by its shedding from the surface of AML blasts, can inhibit the release of interleukin-2 (IL-2), a vital cytokine involved in the activation and function of T cells and NK cells, from immune cells (50).