reported that in addition to a decrease in the population of CD8+ T cells in MDS patients, these cells express high levels of TIM-3, and as expected, TIM-3+ CD8+ T cells express higher perforin and granzyme B and lower CD95 (also known as Fas) compared to TIM-3- CD8+ T cells in MDS patients (27). Here, PRF1 is linked to myelodysplastic syndrome.