ITGB2 and neoplasm: ITGB2 plays a variety of roles in integrin complex, including extracellular matrix formation, Integrin complex formation, leukocyte migration, etc. Through the above functions, the highly expressed ITGB2 can effectively recruit T cells in SKCM TIME and reduce the purity of tumor cells in SKCM, so the overexpression of ITGB2 may effectively improve the effectiveness of immunotherapy against SKCM and improve the overall survival rate.