As some of the genes frequently mutated in age-related clonal hematopoesis such as TET2 and ASXL1 are also commonly mutated in CMML and aged hematopoiesis is characterized by a myelomonocytic differentiation bias it was recently hypothesized that CMML and aged hematopoiesis may be closely related (88). The gene discussed is ASXL1; the disease is chronic myelomonocytic leukemia.