The latest 2017 European Leukemia Net (ENL) guidelines for AML recommends molecular profiling for mutations in NPM1, CEBPA, FLT3-ITD, TP53, RUNX1, ASXL1, and BCR-ABL1. Therefore, the complete cytogenetic and molecular work-up is essential at the time of initial AML evaluation. The gene discussed is FLT3; the disease is acute myeloid leukemia.