We identified a prognostic signature based on nine LncRNAs, namely, MYOSLID, AL139287.1, AC068580.1, AL022328.2, AC104083.1, AL160006.1, AC116914.2, LINC00958, and AL450992.2, to predict OS in HNSCC patients. The gene discussed is MYOSLID; the disease is head and neck squamous cell carcinoma.