CD4 and neoplasm: The analysis showed a marked positive correlation between TLR4 expression in tumor cells and the infiltration of CD8+ T cells (partial.cor=0.506, P=4.47e-33; partial.cor=0.484, P=3.16e-29), CD4+ T cells (partial.cor=0.323, P=3.01e-13; partial.cor=0.246, P=5.63e-08), and DCs (partial.cor=0.749, P=7.99e-89; partial.cor=0.688, P=1.25e-67) in LUAD and LUSC, respectively (Figure 5C).