It can be speculated that the discrepancy in the expressions of CCNB1, CDC20, and CENPF between tumor tissue and peripheral blood may be related to differences in the immune environment: the peripheral circulation has higher percentage of T effectors, such as CD8+T cells, representing cytotoxic T cells, NK cells, and other anti-tumor immune cells than that in HCC tissue where it was dominated by cancer cells and tumor-promoting lymphocytes. This evidence concerns the gene CCNB1 and cancer.