CCNB1 and hepatocellular carcinoma: ROC plots validated that the expression levels of CCNB1 (AUC = 0.905, p < 0.001), CDC20 (AUC = 0.793, p < 0.0001), and CENPF (AUC = 0.872, p < 0.0001) had good diagnostic capabilities in both overall and early-stage (T1) HCC (Figure 2D).