The top 20 co-expressed neighbors were selected, and the core genes PFN1, CALR, thymosin beta 10 (TMSB10), HLA.A, CD74 (HLADG), HLA.DRA, HLA.B, TUBB, and TUBA1A were found to play pivotal roles in the network, suggesting that immune genes are involved in glioma formation (Figure 3B). Here, CALR is linked to central nervous system cancer.