The results of the DEG co-expression network showed that the HLA family (HLA-A, HLA-B, HLA-C, HLA-E, HLA-DRA, HLA-DRB1, and CD74 [HLADG]) plays a vital role in the network, suggesting that tumor immunity is involved in glioma formation. This evidence concerns the gene HLA-DRB1 and glioma.