It has been shown that ARMH4 can interact with and inhibit the function of mTOR complex 2 kinase activity and function as a tumor suppressor in hematological malignancies, which is driven by interleukin 6 (IL-6)–signal transducer and activator of transcription 3 (STAT3) signaling pathways (51, 52). This evidence concerns the gene ARMH4 and hematologic disorder.