Overall, tumor stage (pT2 vs. pT3-4; p<0.001), Gleason score (GS ≤ 7 vs. GS8-10; p=0.003), PSA at time of sRT (<0.5 vs. ≥0.5ng/ml; p<0.001) and radiation dose (<70 vs. ≥70Gy; p<0.001) were the only factors significantly associated with BRFS. This evidence concerns the gene KLK3 and neoplasm.