Furthermore, the increased incidence in NSCLC patients is attributable to the increased association of risk factors for immune-mediated pneumonitis in NSCLC patients including smoking, age >70 years, prior radiotherapy, prior lung disease (including chronic obstructive pulmonary disease), and exposure to the EGFR inhibitor osimertinib (8). The gene discussed is EGFR; the disease is chronic obstructive pulmonary disease.