MMS22L and esophageal squamous cell carcinoma: The MMS22L gene is mapped to chromosome 6 open-reading frame 167, also known as C6orf167. In our study, MMS22L expression in 23 ESCC tissues was notably lower than that in their para-carcinoma tissues, and this trend was consistently observed across the ESCC cell lines and the human normal oesophageal cell line.