DNA methyltransferase 1 (DNMT1), the methyltransferase enzyme that modulates gene expression by methylating cytosine residues within CpG dinucleotides, regulates DNA methylation and is found to be overexpressed in higher in localized, metastatic, and hormone-resistant PCa compared with benign prostate hyperplasia (BPH) (74–77). Here, DNMT1 is linked to posterior cortical atrophy.