MUC4 and cholangiocarcinoma: A meta-analysis which included 4,126 CCA patients highlighted MUC1 and MUC4 as reliable predictors of survival (HR 2.52; 95 % CI 1.49–4.26, and HR 2.45; 95 % CI 1.56–3.86, respectively), especially when combined with EGFR (HR 1.79; 95 % CI 1.14–2.8), fascin (HR 2.58; 95 % CI 1.19–5.58) and the cell cycle marker p27 (HR 0.29; 95 % CI 0.14–0.6) (114).