One study (6) that included 124 patients of NUT carcinoma found that the mOS of nonthoracic primary NUT carcinoma was significantly better than that of thoracic primary NUT carcinomas, and patients with BRD4-NUT fusion had worse mOS than those with BRD3-NUT or NSD3-NUT fusion. This evidence concerns the gene NSD3 and nut midline carcinoma.