In order to determine the relationship between MAPs and the response to CTLA-4 and PD-1 blockers, firstly, we calculated the IPS of 1,037 NSCLC samples exported from TCGA database by TCIA (https://tcia.at/) database (Supplementary Material S1 and Supplementary Table S2). This evidence concerns the gene CTLA4 and non-small cell lung carcinoma.