PAK1 and central nervous system cancer: reported that NUDT21 was up-regulated in human glioma tissues, and NUDT21 promoted the proliferation of glioma cells through the NF-κB signaling pathway (31); in Chu Y et al.’s study, they identified that NUDT21 regulated the alternative polyadenylation of Pak1 and reduced expression of NUDT21 predicted worse survival in low grade glioma and glioblastoma patients (32).