SGPP2 and colitis: Besides, SGPP2 was involved in sphingolipid metabolism, and the defect of sphingolipid metabolism was related to the pathogenesis of SLE (35); induction of SGPP2 expression contributed to the pathogenesis of colitis by promoting the destruction of mucosal barrier function (36); β cell endoplasmic reticulum stress caused by the loss of SGPP2 facilitated the development of diabetes (37).