reported that NUDT21 was up-regulated in human glioma tissues, and NUDT21 promoted the proliferation of glioma cells through the NF-κB signaling pathway (31); in Chu Y et al.’s study, they identified that NUDT21 regulated the alternative polyadenylation of Pak1 and reduced expression of NUDT21 predicted worse survival in low grade glioma and glioblastoma patients (32). The gene discussed is NUDT21; the disease is central nervous system cancer.