PTTG3P and colorectal carcinoma: To evaluate the involvement of the METTL3/PTTG3P/YAP1 axis in CRC proliferation, we carried out a series of rescue experiments in HCT-116 and HT29 cells and found that PTTG3P KD plus METTL3, PTTG3P plus YAP1 KD, and METTL3 plus YAP1 KD could partly recover the proliferative phenotype (Figures 6A–C).