To evaluate the involvement of the METTL3/PTTG3P/YAP1 axis in CRC proliferation, we carried out a series of rescue experiments in HCT-116 and HT29 cells and found that PTTG3P KD plus METTL3, PTTG3P plus YAP1 KD, and METTL3 plus YAP1 KD could partly recover the proliferative phenotype (Figures 6A–C). This evidence concerns the gene YAP1 and colorectal carcinoma.