NFKB1 and colorectal carcinoma: Suppression of phosphorylation and activity of NF-κB subunits could be a potential therapy and chemopreventive intervention in colon carcinogenesis by Calebin A. To support this assumption, in previous studies, Calebin A treatment was found to sensitize human lung, cervical cancer, and CRC cells to paclitaxel or cisplatin or 5-FU effectively inhibiting the NF-κB pathway (23, 37, 39).