Based on our findings and the role TNFR1 and TNFR2 receptors play, we recommend further study of the biochemical pathways of TNF alpha, which will further allow for the synthesis of selective TNFR1 inhibitors or TNFR2 agonists as treatment modalities for patients with RA and concomitant cardiovascular disease. The gene discussed is TNFRSF1B; the disease is rheumatoid arthritis.