KCNH1 and familial hypercholesterolemia: Genetic factors such as angiotensin-converting enzyme DD genotype polymorphism [11], abnormal lipoprotein metabolism associated with familial hypercholesterolemia [12], potassium voltage-gated channel subfamily H member 1 (KCNH1) mutation [13], and autophagy related 16 like 1 (ATG16L1) gene mutations [14] have all been linked to CAE previously.