Yasar et al. discovered that 32 patients with isolated CAE without associated coronary artery stenosis had significantly higher levels of P-selectin, beta-thromboglobulin, and platelet factor 4 (PF4) compared to a control group with normal coronary arteries (P<0.001), indicating increased platelet activation in these patients [17]. The gene discussed is PF4; the disease is coronary stenosis.