For example, the PARADIGM-HF (Prospective Comparison of ARNI with ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure) trial demonstrated that sacubitril-valsartan, a combination of neprilysin inhibitor and angiotensin receptor blocker, was superior to enalapril in reducing deaths and hospitalizations due to heart failure [18]. Here, MME is linked to heart failure.