Glucocorticoids provide beneficial effects after acute CNS injury in humans and experimental animals. Important data show that glucocorticoids may have a disease-modifying effect in addition to anti-inflammatory actions Glucocorticoids are among a variety of endogenous compounds that have been suggested to influence melatonin production Among animal models of Alzheimer’s disease, melatonin has been found to reduce ROS, block apoptosis, have antiinflammatory effect, improve spatial memory, and protects wortmannin-induced tau hyperphosphorylation. The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.