It was also noted that cells along the invasive edges were positive for sodium-hydrogen exchanger (NHE-1) and the glucose transporter (GLUT-1) by immunohistochemical analysis, which were recognized to be associated with an acidic tumor microenvironment. GLUT-1 is an enzyme that allows the entry of glucose into cells, which is why it is important in facilitating the Warburg effect. Here, SLC2A1 is linked to neoplasm.