NPPB and hydrops fetalis: The Comparison of Sacubitril/Valsartan Versus Enalapril on Effect on NT-proBNP in Patients Stabilized From an Acute Heart Failure Episode (PIONEER-HF) trial provides evidence on the efficacy of sacubitril-valsartan in contrast to enalapril in patients with acute heart failure demonstrated by a more significant reduction in the N-terminal proB-type natriuretic peptide (NT-proBNP) concentration [7].