DVL1 and colon adenocarcinoma: As shown in Figure 1A, using the TIMER database we found that DVL-1 was significantly upregulated in various cancer types which have hyper-activated Wnt signaling including breast cancer, colon adenocarcinoma, liver hepatocellular carcinoma, lung adenocarcinoma, prostate adenocarcinoma compared to adjacent normal (healthy) tissues [14, 15].