Particularly, the expression levels of DVL-1 was negatively and significantly correlated with 16 immune cell gene markers in TNBC breast cancer, such as CD2, CD86, CCL2, CD68, IL10, MS4A4A, KIR3DL2, HLA-DRA, HLA-DPA1, STAT4, STAT1, GATA3, IL21, CCR8, CTLA4, and HAVCR2. The gene discussed is IL21; the disease is breast cancer.