We obtained positive IgE-binding results with specific IgEs from the serum of individuals with strong HDM allergies (sIgE) for Der f petrotrophic-like protein [positive rate: 21.4%, 41/192 in IgE-enzyme-linked immunosorbent assay (ELISA); 4/10 in IgE-western blot (WB); 4/10 in IgE-dot ELISA] (Fig. 1C-D and Fig. S3). This evidence concerns the gene IGHE and allergic disease.