Several virologic and treatment-related factors are believed to play a role in the pathophysiology of hypertension in HIV infection, including chronic inflammation, immune reconstitution, and lipodystrophy, of which, all seem to directly or indirectly influence common downstream pathways such as the sympathetic and renin-angiotensin-aldosterone systems (RAAS) [10]. The gene discussed is REN; the disease is lipodystrophy.