In A549 cell line, PRDM5 has been shown to be silenced by previous studies.Not surprisingly, we found that PRDM5 knockdown GC cells (AGS, SGC7901) significantly enhanced their proliferation ability (Figure 3A-B) and the ectopic expression of PRDM5 inhibited the proliferation of tumor cells (Figure 3D-E). Here, PRDM5 is linked to gastric cancer.