Univariate logistic regression analysis in TCGA cohort confirmed that the crucial variables for the risk of incidence rate of classical histological type were the expression of SYT12 (P<0.001), lymph node metastasis (P<0.001), primary neoplasm focus type (P=0.002), tumor stage (P=0.032), distant metastasis (P=0.033) and status (P=0.026) (Table 5). Here, SYT12 is linked to neoplasm.