IGFBP1 and cancer: Previous studies have demonstrated that HNF-1β regulates the gene/protein expression such as annexin A4, osteopontin, uridine diphosphate (UDP)-glucuronosyl transferase 1A1 (UGT1A1), and insulin-like growth factor-binding protein 1 (IGFBP-1), which are vital for cancer progression 88.