In order to further clarify the expression level of IRF6 and its clinical role in ccRCC, we examined the protein expression of IRF6 in 50 ccRCC tissues and 20 matched adjacent normal renal tissues using immunohistochemistry staining, and the detailed clinicopathological characteristics of these 50 ccRCC patients was shown in Table 3. This evidence concerns the gene IRF6 and nonpapillary renal cell carcinoma.