IRF6 and nonpapillary renal cell carcinoma: Our results showed that IRF6 protein expression was decreased in multiple ccRCC cell lines (786-O, OSRC2, Caki-1 and A498) compared to HK2 cell line (Figure 6B), and the DNA methylation levels of these ccRCC cell lines were increased than that in HK2 cell line (Figure 6C).