For instance, IRF8 functions as a tumor suppressor in RCC, and its mediated interferon signal pathway is involved in the pathogenesis of RCC 23; RCC patients with high IRF8 expression level have prolonged OS compared to patients with low level of IRF8 expression 24; IRF1 plays a pivotal role in the interferon-gamma-mediated-enhancement of Fas/CD95-mediated RCC cells apoptosis 25. This evidence concerns the gene IRF1 and renal cell carcinoma.