Results showed that IRF6 expression, compared with adjacent normal renal tissues, was significantly decreased in ccRCC (Figure 1A), and decreased IRF6 expression was related to higher histological grade (G3/G4) (Figure 1B), advanced tumor stage (T3/T4) (Figure 1C), higher pathological stage (Stage III/IV) (Figure 1D) and distant metastasis (Figure 1E). This evidence concerns the gene IRF6 and neoplasm.