Considering that the number size of normal tissue in the TCGA database is too small to be statistically convincing (e.g., TCGA glioblastoma multiforme (GBM) cohort has only five normal controls), we integrated the GTEx and TCGA databases to reflect the KLRB1 mRNA expression landscape in a more convincing manner, and found that KLRB1 mRNA level was consistently elevated in most cancers including ACC, BLCA, CESC, CHOL, COAD, ESCA, GBM, HNSC, KIRC, LAML, LGG, LUSC, OV, PAAD, PRAD, SKCM, STAD, TGCT, THCA, and UCS compared to GTEx normal controls (Figure 1B). The gene discussed is KLRB1; the disease is cancer.