Furthermore, to clarify whether hsa_circ_0001306 play roles in HCC via sponge of miR-527 and by means of FBXW7, we then detected the mRNA and protein expression levels of FBXW7 in Hep-G2 and SK-HEP-1 cells after transfection of siRNAs targeting hsa_circ_0001306 (Figure 6F-I). Here, FBXW7 is linked to hepatocellular carcinoma.