For examples, in osteosarcoma, colorectal cancer, liver cancer and breast cancer, miR-328-3p overexpression inhibited their migration, invasion, and EMT by directly inhibiting MMP-16, Girdin, Endoplasmic Reticulum Metallo Protease 1 (ERMP1) and CD44, respectively 17, 26-29. The gene discussed is CCDC88A; the disease is liver cancer.