In addition, HNSCC cells co-transfected with miR-328-3p mimic and H2AFX plasmid exhibited stronger migration and invasion capacities than those co-transfected with NC and H2AFX plasmid, which again proved that miR-328-3p can promote the migration and invasion of HNSCC cells (Fig. 6E, F). The gene discussed is H2AX; the disease is head and neck squamous cell carcinoma.