Altogether, these findings and evidences suggested that silencing LINC00152 can inhibit tumor formation and glycolysis in pancreatic cancer cells through KLF7, and over-expression of KLF7 may promote the proliferation of PC cells in vivo by promoting the glycolysis of PC cells, and thus restore the growth of tumors. The gene discussed is KLF7; the disease is pachyonychia congenita.