AKT1 and cancer: Pathways that were associated with downregulated genes were mainly associated with adhesion, ECM-receptor interaction, the PI3K-Akt signaling pathway, protein digestion and absorption, the calcium signaling pathway, regulation of the actin cytoskeleton, vascular smooth muscle contraction, cancer pathways, cGMP-PKG signaling pathway, neuroactive ligand-receptor interaction, proteoglycan in cancer, the MAPK signaling pathway, the GABAergic synapse, the Wnt signaling pathway, and the cAMP signaling pathway (Figure 9(b)).