It can be seen from Table 1 that the above Tibetan medicines can protect the kidney by improving the expression of related factors (TGF, HIF-1α, VEGF, SOD, etc.)in renal tissue, inhibiting the damage of renal epithelial cells, alleviating renal fibrosis, scavenging free radicals, and inhibiting lipid peroxidation and other ways, and play a role in the treatment of DN. Here, HIF1A is linked to renal fibrosis.