Exosomes enriched with HSP70 were secreted from prostate cancer cells, inducing the engagement of TLR2 and phosphorylation of NF-κB, resulting in upregulating expression of CXCR4 in MDSCs and eventually leading to the accumulation of MDSCs into tumor microenvironment (TME). Here, NFKB1 is linked to prostate carcinoma.