It has been reported that as tumor cells metastasize to lymph nodes and progression of disease stages, the immune response shifts from an inflammatory state to an inhibited state, with a decrease in proinflammatory and antitumor cytokines, IL17 and IFNγ, and an increase in protumor phenotypes, Th2 and Treg cells [43]. This evidence concerns the gene IFNG and neoplasm.