AFP and neoplasm: Multivariate analysis using the five mentioned factors revealed that NEIL3 expression (HR 1.980; 95% CI 1.159–3.380; P=0.012), TNM stage (HR 10.529; 95% CI 1.399–79.261; P=0.022), AFP (HR 1.967; 95% CI 1.073–3.605; P=0.029), tumor size (HR 2.171; 95% CI 1.242–3.796; P=0.007), and tumor differentiation (HR 2.032; 95% CI 1.223–3.376; P=0.006) serve as independent prognostic factors for OS (Table 2).