Recent study also elicited that peroxisome ATP binding cassette, subfamily D, member 2 (ABCD2), in osteoarthritis chondrocytes can affect miR-141 expression, downregulate the expression of acyl-CoA synthetase 4 (ACSL4), and thus induce the accumulation of very long chain fatty acids (VLCFAs) [18]. This evidence concerns the gene ACSL4 and osteoarthritis.