Angiogenesis and metastasis are the major causes of tumor progression, and during tumor progression, integrins interact with extracellular matrix molecules such as vitronectin, collagen, or glycolipids to trigger signal the transduction involved in cell migration and tumor metastasis, and high integrin αV expression is promoted by BRD1-mediated acetylation (Cai et al., 2018). Here, VTN is linked to neoplasm.