While TWEAK-FN14 activation is beneficial in the context of acute tissue injury, persistent activation can lead to chronic inflammation, tissue damage, and fibrosis; TWEAK-FN14 signaling is also dysregulated in autoimmune diseases (Dostert et al., 2019) and in asthma (Tessier et al., 2017). This evidence concerns the gene TNFRSF12A and asthma.