Taken together, downregulation of AGPAT2 and DTX4 supports the accumulation of LPA and free fatty acids (FAs) and alters the excess lipid storage in the inert form of triglycerides in the cellular lipid droplets (Figure 7), which can be seen in the COVID-19 plasma lipidome (Wu et al., 2020). The gene discussed is DTX4; the disease is COVID-19.