IL22 and Autoimmunity: IL12 activates type 1 immunity (TH1-defence against viruses and intracellular bacteria, inflammation/autoimmunity, IFN-γ) and IL23 activates type 3 immunity (TH17-defence against extracellular bacteria and fungi, inflammation/autoimmunity, IL22), (Annunziato et al., 2015).