The virus also supports type 2 immunity (immunity defense against helminths and venoms, IL4 cytokine, allergy/asthma; Annunziato et al., 2015); the virus represses DENND1B, INHBA, KHSRP, and YTHDF1, which represent the second circle that can lead to self-perpetuating inflammation–inflammatory storm. This evidence concerns the gene DENND1B and allergic disease.