Functionally, MID1 induces protein translation of its target mRNAs (Krauss et al., 2013; Hettich et al., 2014; Köhler et al., 2014; Griesche et al., 2016), and in HD cell models, the interaction of MID1 and mutant HTT RNA leads to an increased translation rate of neurotoxic polyglutamine protein (Krauss et al., 2013). This evidence concerns the gene HTT and Huntington disease.