CCL2 and Familial prostate cancer: Moreover, in prostate cancer, C-C motif chemokine ligand 2 (CCL2) is a main target of PRC1, and the H3K27me3 inhibitory marker that is bound with CBX7 is relatively low in the promoter region of the CCL2 gene, which leads to massive production of CCL2 (Su et al., 2019).