In addition, we also found that high mutations in USH2A and NEB genes in high-risk groups lead to decreased infiltration of CD4 + T lymphocytes and CD8 + T lymphocytes in tumor centers and increased infiltration of Treg cells, which may be a factor leading to the characteristics of active immune response and low invasive tumor phenotype in patients in the low risk group. Here, CD8A is linked to neoplasm.