Among the 5-lncRNA signature of ESCC, lncRNA HOXB-AS3 has been found to be abnormally expressed in non-small cell lung cancer, colon cancer, and acute myeloid leukemia (Huang et al., 2017; Huang et al., 2019; Jiang et al., 2020). This evidence concerns the gene PDS5B and acute myeloid leukemia.