Only common lymphoid progenitors, γδT cells, resting CD4+ memory T cells, resting NK cells, and M0 macrophages presented negative correlation in ESCC, while the mast cells, naïve CD4+ T cells, and M0 macrophages were negatively related to risk in EAC (Supplementary Table S11). This evidence concerns the gene CD4 and esophageal squamous cell carcinoma.