According to the previous studies, the increase of IL-17-releasing mast cells can be a potential prognostic marker and were positively correlated with CD8+T cells and macrophages in the same site in ESCC, indirectly mediating their tumor activity by promoting the recruitment of other effector immune cells (Gong et al., 2019; Han et al., 2020). This evidence concerns the gene CD8A and esophageal squamous cell carcinoma.