Our results revealed significantly dysregulated genes that are associated with cell death and survival, including TGFBR1, RBM5, THOC2, USP11, MDM2, TPP2, EIF4E, VRK1, CCNA2, ZMAT3, AGPAT2, H2AFX, CREB1, FIGNL1, and GSK3B. Identifying the characteristics of these genes and their network of interaction is important to understand the pathophysiology of HCC and discover new therapeutic targets for the disease. This evidence concerns the gene CREB1 and hepatocellular carcinoma.